New key paper available!

Consult now the full PDF version of Renal Sympathetic Denervation, a chapter written by Tomas F. Lüscher, Ulf Landmesser, Mathias Wolfrum, Georg Noll and Isabelle Sudano.


Arterial hypertension represents a significant global health issue. Despite lifestyle modification and pharmacological approaches, worldwide, the achievement rates of blood pressure control remain unsatisfactory. Both experimental and clinical studies have emphasised the important role of sympathetic nervous system activation in the development and progression
of arterial hypertension. Catheter-based renal denervation is a new therapeutic option to reduce renal sympathetic nervous activation in experimental and human hypertension. The data so far obtained in patients with drug-resistant hypertension has demonstrated that this procedure may reduce blood pressure effectively and safely.
Targeting the renal sympathetic nerves could also be an attractive future strategy for other diseases, where the activation of the sympathetic nervous system plays an important pathophysiological role; such as in sleep apnoea syndrome, heart failure, chronic kidney disease or polycystic ovary syndrome.

This chapter also includes supplementary data which can be found in the online version available here